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目的:观察血管内皮生长因子(VEGF)水平对成人过敏性紫癜肾炎(HSPN)的影响。方法:选择成人HSPN 32例为观察组,另选择健康成人32例为对照组,采用酶联免疫吸附法测定血清VEGF,比较两组血清VEGF水平。同时,根据观察组不同病情,测定并比较轻、中、重型患者血清VEGF水平。结果:观察组血清VEGF水平非常显著高于对照组(P<0.01);轻、中型患者血清VEGF水平非常显著高于重型患者和对照组(P<0.01);重型患者血清VEGF水平非常显著低于对照组(P<0.01)。结论:成人HSPN血清VEGF水平显著升高,可在一定程度上反映病情的轻重和预后。
Objective: To observe the effect of vascular endothelial growth factor (VEGF) on adult HSPN. Methods: Thirty-two adult HSPNs were selected as observation group. Another 32 healthy adults were selected as control group. Serum VEGF levels were measured by enzyme-linked immunosorbent assay (ELISA). Serum VEGF levels were compared between the two groups. At the same time, according to the observation group of different conditions, determination and comparison of mild, moderate and severe serum VEGF levels. Results: The serum level of VEGF in the observation group was significantly higher than that in the control group (P <0.01). The levels of serum VEGF in the patients with mild to moderate disease were significantly higher than those in the severe patients and the control group (P <0.01) Control group (P <0.01). Conclusion: The serum VEGF level of HSPN in adults is significantly increased, which can reflect the severity and prognosis of HSPN to a certain extent.