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目的探究盐酸普拉克索联合葛根素注射液对帕金森病(PD)患者血清脑源性神经营养因子(BDNF)和胱抑素C(CysC)水平的影响。方法选取2014年2月至2016年12月平顶山市第一人民医院收治的PD患者74例,按随机数表法分为两组,各37例。给予对照组盐酸普拉克索治疗,给予观察组盐酸普拉克索+葛根素注射液治疗。统计对比两组患者的治疗效果及治疗前后血清BDNF和CysC水平。结果观察组患者的治疗总有效率高于对照组(89.19%比67.57%),差异有统计学意义(P<0.05)。治疗前,两组患者血清BDNF和CysC水平比较,差异均无统计学意义(P>0.05);治疗后,两组血清BDNF水平均升高,且观察组高于对照组,两组血清CysC水平均降低,且观察组低于对照组,差异均有统计学意义(P<0.05)。结论盐酸普拉克索联合葛根素注射液治疗帕金森病效果显著,可提高患者血清BDNF水平,降低血清CysC水平,值得推广。
Objective To investigate the effects of pramipexole hydrochloride combined with puerarin on serum brain-derived neurotrophic factor (BDNF) and cystatin C (CysC) in patients with Parkinson’s disease (PD). Methods From February 2014 to December 2016, 74 cases of PD patients admitted to the First People’s Hospital of Pingdingshan City were divided into two groups (n = 37) according to random number table. Pramipexole hydrochloride was given to the control group, and pramipexole hydrochloride plus puerarin injection was given to the observation group. Statistics were compared between the two groups of patients with treatment and serum BDNF and CysC levels before and after treatment. Results The total effective rate of observation group was higher than that of control group (89.19% vs 67.57%), the difference was statistically significant (P <0.05). Before treatment, the levels of serum BDNF and CysC were not significantly different between the two groups (P> 0.05). After treatment, serum BDNF levels in both groups were increased, and the observation group was higher than the control group. The levels of serum CysC Were lower, and the observation group was lower than the control group, the difference was statistically significant (P <0.05). Conclusion Pramipexole hydrochloride combined with puerarin injection is effective in treating Parkinson’s disease, which can improve serum BDNF level and decrease serum CysC level, which is worthy of promotion.