【摘 要】
：
目的 对比二次电切加术中黏膜下膀胱注射吡柔比星与单次电切术后即刻灌注吡柔比星预防浅表膀胱癌复发的疗效.方法 47例表浅性膀胱癌患者随机分为观察组、对照组.观察组25例行
【机 构】
：
青岛市胶州中心医院泌尿外科,山东青岛,266300
论文部分内容阅读
目的 对比二次电切加术中黏膜下膀胱注射吡柔比星与单次电切术后即刻灌注吡柔比星预防浅表膀胱癌复发的疗效.方法 47例表浅性膀胱癌患者随机分为观察组、对照组.观察组25例行2次电切手术,第二次在术中给予30 mg吡柔比星膀胱黏膜下注射；对照组22例单次电切术后6h内给予30 mg吡柔比星膀胱灌注.出院后3、6、12个月检查1次膀胱镜,1年后半年检查1次,观察两组间肿瘤复发率差异.结果 随访17～35个月(平均24个月),观察组有4例(16.0％)肿瘤复发；对照组有7例(31.8％)肿瘤复发.所有患者未见明显全身药物不良反应.结论 二次电切加术中黏膜下膀胱注射吡柔比星能显著降低膀胱癌患者术后复发率,其效果优于单次电切后即刻膀胱灌注.
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