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背景:应用抗肿瘤药物治疗(简称化疗)已成为大肠癌患者的重要辅助治疗方法,然而对化疗药物的敏感性存在较大的个体差异,其差异是否与患者的年龄及性别有关?目的:采用流行病学调查方法探讨根据肿瘤细胞存活率对药物在不同年龄以及不同性别之间大肠癌患者中的作用有否差异。设计:以病理标本为研究对象的对照实验研究。单位:一所医学院附属医院普外科。对象:以2001-01/2003-01川北医学院附属医院普外科收治的169例大肠癌患者的癌肿标本为研究对象(均经手术切除和病理证实)。患者男97例,女72例。所有病例术前均未使用抗癌药物。方法:用体外肿瘤药敏试验四唑盐比色法对169例新鲜人大肠癌标本进行化疗药物敏感性检测,分析在患者不同年龄及不同性别之间的差异。主要观察指标:肿瘤细胞经各种抗癌药物作用72h后的吸光度值。结果:大肠癌患者化疗药物的敏感性与不同年龄以及不同性别的差异均无显著性意义(P>0.05)。结论:大肠癌患者对化疗药物敏感性的个体差异与患者的年龄及性别无关,针对大肠癌不同个体筛选敏感药物可不考虑年龄及性别因素。
BACKGROUND: The application of antineoplastic drugs (referred to as chemotherapy) has become an important adjuvant therapy for patients with colorectal cancer. However, there is a large individual difference in the sensitivity to chemotherapeutic drugs. Is the difference related to the age and gender of the patients? OBJECTIVE: Epidemiological survey method to explore the survival rate of tumor cells on the drug in different age groups and different gender differences in the role of colorectal cancer patients. Design: A controlled experimental study of pathological specimens. Unit: a General Surgery Hospital Affiliated Hospital. PARTICIPANTS: A total of 169 patients with colorectal cancer who underwent general surgery in the Affiliated Hospital of North Sichuan Medical College from January 2001 to January 2003 were selected as the study subjects (both surgically resected and confirmed by pathology). There were 97 males and 72 females. All cases did not use anti-cancer drugs before surgery. Methods: Tumor sensitivity test in vitro tetrazolium salt colorimetric assay of 169 cases of fresh human colorectal cancer specimens for chemotherapeutic drug susceptibility testing, analysis of patients at different ages and different gender differences. MAIN OUTCOME MEASURES: Absorbance values of tumor cells after 72 hours by various anticancer drugs. Results: There was no significant difference in chemosensitivity between patients with colorectal cancer and those of different ages and genders (P> 0.05). Conclusion: The individual differences of chemosensitivity in patients with colorectal cancer have nothing to do with the age and sex of patients. Screening sensitive drugs for different individuals of colorectal cancer may not consider the age and gender factors.