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目的:探讨乳腺癌患者中医证型与瘦素(LEP)水平在化疗前后变化的相关性。方法:选择在本院诊治的132例乳腺癌术后患者作为研究对象,所有患者都在化疗前后进行瘦素的检测。结果:所有患者化疗后的瘦素水平都高于化疗前(P<0.05);脾虚痰湿型患者化疗前后的瘦素差值变化与其他分型患者对比差异也有统计学意义(P<0.05)。结论:乳腺癌患者中医证型与化疗前后体内瘦素变化有很好的相关性,其中脾虚痰湿型患者的瘦素水平在化疗前与化疗后的变化最明显。
Objective: To investigate the correlation between TCM syndrome type and the level of leptin (LEP) in patients with breast cancer before and after chemotherapy. Methods: 132 cases of postoperative breast cancer patients treated in our hospital were selected as the study subjects, and all patients were tested for leptin before and after chemotherapy. Results: The levels of leptin in all patients after chemotherapy were significantly higher than those before chemotherapy (P <0.05). The changes of leptin difference before and after chemotherapy in patients with spleen phlegm-dampness were also significantly different from those in other patients (P 0.05) . Conclusion: There is a good correlation between the TCM syndromes of breast cancer patients and the change of leptin before and after chemotherapy. The leptin level of patients with phlegm-dampness type of spleen deficiency before and after chemotherapy is the most obvious.