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为探讨胚胎期及新生期大鼠胃肠道的胰岛淀粉样多肽（ＩＡＰＰ）与其他生物活性物质的关系，用免疫组织化学ＰＡＰ法，在相邻切片上分别显示第１５～２１ｄ大鼠胚胎及新生大鼠胃肠道的ＩＡＰＰ免疫反应性（ＩＲ）细胞和生长抑素（ＳＳ）ＩＲ细胞，观察了ＩＡＰＰ与ＳＳ在胚胎及新生大鼠胃肠道的定位分布。结果表明：第１５ｄ胚胎，胃肠道内未见ＩＡＰＰ－和ＳＳ－ＩＲ细胞。第１７ｄ胚胎，ＩＡＰＰ－与ＳＳ－ＩＲ细胞均很少，免疫染色较弱，着色较浅，免疫反应性细胞散布于分化未完全的肠上皮细胞间。胚胎１９ｄ，ＩＡＰＰ－和ＳＳ－ＩＲ细胞出现于胃和小肠，以十二指肠为多。胚胎第２１ｄ及新生期，胃肠道各段均可见到ＩＡＰＰ－和ＳＳ－ＩＲ细胞。经邻片比较证明，胚胎第１９ｄ始至新生期，十二指肠和空肠中部分ＩＡＰＰ－ＩＲ细胞与部分ＳＳ－ＩＲ细胞的定位相同，表明ＩＡＰＰ与ＳＳ在十二指肠和空肠Ｄ细胞中有共存。胃、回肠、结肠和直肠未见到ＩＡＰＰ与ＳＳ有细胞内共存的现象。本文对上述结果的意义进行了讨论
To investigate the relationship between amylin (IAPP) and other biologically active substances in the gastrointestinal tract of embryonic and neonatal rats, immunohistochemical PAP method was used to detect the expression of IAPP in the rat embryos on the 15th to 21st day The IAPP immunoreactive (IR) cells and somatostatin (SS) IR cells in the gastrointestinal tract of neonatal rats were used to observe the distribution of IAPP and SS in the gastrointestinal tract of embryonic and neonatal rats. The results showed that IAPP- and SS-IR cells were not found in the embryo on day 15 and in the gastrointestinal tract. On the 17th embryo, IAPP- and SS-IR cells were rare, the immunostaining was weaker, the coloration was lighter, and the immunoreactive cells scattered among incompletely differentiated intestinal epithelial cells. On embryonic day 19, IAPP- and SS-IR cells appeared in the stomach and small intestine, mostly in the duodenum. On the 21st day of embryo and neonatal period, IAPP- and SS-IR cells were found in all stages of gastrointestinal tract. The comparison of adjacent flanks showed that the IAPP-IR cells in the duodenum and jejunum from the 19 th day to the neonate stage of the embryo had the same location as some SS-IR cells, indicating that IAPP and SS were located in the duodenum and jejunum D cells There is coexistence. Stomach, ileum, colon and rectum IAPP and SS did not see the phenomenon of intracellular coexistence. This article discusses the significance of the above results