论文部分内容阅读
目的评价美施康定治疗癌性疼痛的效果并观察其毒副作用。方法1995.11～1998．6，103例病人接受美施康定治疗。男性78例，女性25例；年龄32～81岁（中位年龄58岁）。73例病人同时接受其他的抗癌姑息冶疗，其中化疗31例，放疗10例，内分泌治疗6例，抗骨溶解治疗（博宁、阿可达）14例，化疗与放疗相结合治疗12例。肿瘤病人以肿痛为主，其它有肝癌、乳癌、鼻咽癌和消化道肿瘤病人。结果止痛的有效率为8835％（91／103），平均止痛剂量为80mg／天，平均初始剂量和最大剂量分别为45．5mg／天／112．8mg／天。疼痛平均缓解时间为9周。21．39％（21/103）病人增加剂量（其中19例为单独止痛药运用组），16.51％（17／103）需要减少剂量（其中16例为联合其他抗癌治疗组）。主要副作用是便秘和恶心呕吐。结论每天两次中等剂量的美施康定治疗癌性疼痛是相当有效的．而且副作用轻，可以耐受，与其他抗癌姑息治疗联用有协同增效作用。
Objective To evaluate the efficacy of Methiconidine in the treatment of cancer pain and observe its toxic and side effects. Methods From 1995.11 to 1998.6, 103 patients received metsulfide treatment. There were 78 males and 25 females; aged 32-81 years (median age: 58 years). 73 patients received other anti-cancer palliative care at the same time, including chemotherapy in 31 cases, radiotherapy in 10 cases, endocrine therapy in 6 cases, anti-osteolysis treatment (Bonin, Argao) in 14 cases, chemotherapy and radiotherapy in combination with 12 cases . Tumor patients are mainly swollen and painful. Others include patients with liver cancer, breast cancer, nasopharyngeal cancer and digestive tract cancer. Results The effective rate of analgesia was 8835% (91/103). The average analgesic dose was 80 mg/day. The average initial dose and maximum dose were 45.5 mg/day/112.8 mg/day, respectively. The average pain relief time was 9 weeks. 21.39% (21/103) patients increased their doses (19 of them were in the analgesic group alone), and 16.51% (17/103) needed dose reductions (16 of them were combined with other anticancer treatments). The main side effects are constipation and nausea and vomiting. 2. Conclusion Two times a day dose of metstaining for cancer treatment is quite effective. And the side effects are mild and can be tolerated, and synergistically with other anti-cancer palliative treatments.