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β-内酰胺抗生素酰胺菌素(Aztreonam 简称A)口服无效,常将其配成10或20 mg/ml 的注射液供用。实验:将灭菌粉针(Ⅰ)和磷酸氯林可霉素注射液(150mg/ml)(Ⅱ),分别以0.9%氯化钠注射液或5%葡萄糖注射液作为稀释液,配制成注射混合液,两药物浓度分别为:20 mg/ml(Ⅰ)+6 mg/ml(Ⅱ);20 mg/ml(Ⅰ)+3 mg/ml(Ⅱ);10 mg/ml(Ⅰ)+6 mg/ml(Ⅱ);10 mg/ml(Ⅰ)+3 mg/ml(Ⅱ)。置于4℃下7天和22～23℃(室温)48 h,于一定间隔时间内,抽样观察样品结晶情况,并用HPLC 法,于紫外205 nm 波长处检测A 的浓度。
The beta-lactam antibiotic Aztreonam (A) is not orally available and is often given as an injection at 10 or 20 mg / ml. Experimental: The sterile powder injection (Ⅰ) and clindamycin phosphate injection (150mg / ml) (Ⅱ), respectively, with 0.9% sodium chloride injection or 5% glucose injection as a diluent, formulated as injection The concentration of the two drugs in the mixture was 20 mg / ml (Ⅰ) +6 mg / ml (Ⅱ), 20 mg / ml (Ⅰ) +3 mg / ml mg / ml (II); 10 mg / ml (I) +3 mg / ml (II). The sample was observed at a certain interval time and stored at 4 ℃ for 7 days and 22 ~ 23 ℃ (room temperature) for 48 hours. The concentration of A was detected by HPLC at UV wavelength of 205 nm.