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血浆纤维蛋白原是人体凝血系统的主要凝血因子,其浓度升高是冠状动脉粥样硬化性心脏病(CHD)发病的一个独立危险因素,而且其浓度的变化与环境、遗传因素有关。笔者就血浆纤维蛋白原的影响因素以及其与心血管疾病发生的相关性做一综述。1 纤维蛋白原的结构和功能 人纤维蛋白原(凝血因子Ⅰ)在肝脏中合成,是一种糖蛋白,每一个纤维蛋白原分子由三对非等同的多肽链Aa_2、Bβ_2
Plasma fibrinogen is the main clotting factor in the human coagulation system. Elevated concentrations of fibrinogen are an independent risk factor for coronary heart disease (CHD), and its concentration changes are related to the environment and genetic factors. The author of the impact of plasma fibrinogen and its relationship with the occurrence of cardiovascular disease to do a review. Structure and function of fibrinogen Human fibrinogen (factor I) is synthesized in the liver, is a glycoprotein, each fibrinogen molecule consists of three pairs of non-identical polypeptide chains Aa_2, Bβ_2