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目的:观察注射用七叶皂苷钠辅助治疗结核性脑膜炎的临床疗效。方法:2008年1月—2010年10月收治结核性脑膜炎患者52例,单纯西药治疗作为对照组,2011年1月—2013年12月收治结核性脑膜炎患者52例,单纯西药治疗基础上加用七叶皂苷钠治疗作为观察组。结果:注射用七叶皂苷钠在结核性脑膜炎治疗中头疼完全缓解时间平均为(10.2±6.3)天,脑脊液压力恢复正常时间平均为(12.6±7.8)天,脑脊液生化、常规恢复时间平均为(20±11.5)天,而对照组52例分别为(15.7±6.5)天,(18.4±6.4)天,(28.6±12.4)天。两组比较差异有统计学意义(P<0.01)。结论:注射用七叶皂苷钠可常规静点治疗结核性脑膜炎,改善病情,缓解脑水肿,最终改善预后。
Objective: To observe the clinical efficacy of sodium aescinate injection for the treatment of tuberculous meningitis. Methods: From January 2008 to October 2010, 52 patients with tuberculous meningitis were treated. Western medicine alone was used as a control group. From January 2011 to December 2013, 52 patients with tuberculous meningitis were admitted. On the basis of western medicine alone Plus sodium aescinate treatment as observation group. Results: Aescinate sodium for treatment of tuberculous meningitis headache complete remission time averaged (10.2 ± 6.3) days, the average time to normal cerebrospinal fluid pressure was (12.6 ± 7.8) days, cerebrospinal fluid biochemical and routine recovery time was (20 ± 11.5) days, while the control group, 52 cases were (15.7 ± 6.5) days, (18.4 ± 6.4) days, (28.6 ± 12.4) days. The difference between the two groups was statistically significant (P <0.01). Conclusion: Sodium aescinate for injection can routinely treat tuberculous meningitis, improve the condition, relieve cerebral edema and finally improve the prognosis.