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目的:总结全身型幼年特发性关节炎(So JIA)的治疗方案及临床疗效。方法:回顾性分析2006年1月至2011年7月我科收治的104例So JIA患儿的临床资料。结果:本组104例患儿中,NSAIDs联合MTX治疗,仅3例患儿达完全缓解。两者再联合激素治疗,27例患儿可达完全缓解,13例达部分缓解,“三联疗法”总有效率为40.9%。在“三联疗法”无效的情况下联合使用其它DMARDs药物,其中6例失访,1例因合并MAS死亡,其余患儿均得到完全或部分缓解。结论:NSAIDs联合MTX治疗So JIA对于相当一部分病例并未能有效退热及改善关节炎症状,需加用激素治疗,对于难治性So JIA,联合使用CTX等其它DMARDs药物能增加病情缓解率,提高疗效。
Objective: To summarize the treatment and clinical efficacy of systemic juvenile idiopathic arthritis (So JIA). Methods: The clinical data of 104 children with So JIA admitted to our department from January 2006 to July 2011 were retrospectively analyzed. Results: Among the 104 infants in this group, NSAIDs combined with MTX treatment achieved complete remission in only 3 patients. Both combined hormone therapy, 27 cases of children up to complete remission, 13 cases of partial remission, “triple therapy ” total effective rate was 40.9%. In combination with other DMARDs in the absence of triple therapy, six were lost to follow-up and one died of combined MAS, leaving the remaining children either completely or partially relieved. Conclusion: NSAIDs combined with MTX treatment of So JIA for a considerable number of cases did not effectively reduce fever and improve the symptoms of arthritis, the need to add hormonal therapy, for refractory So JIA, combined with CTX and other DMARDs drugs can increase the rate of remission, Improve the curative effect