目的：观察尼尔雌醇对绝经期妇女血脂及血液流变学的影响。方法：３０例绝经期妇女口服尼尔雌醇５ｍｇ，ｐｏ，每月１次，疗程３ｍｏ，分别于服药前后查血脂及血液流变学。结果：ＬＤＬ＿ｃｈ，ＬＤＬ＿ｃｈ／ＨＤＬ＿ｃｈ较服药前显著下降，ＡｐｏＡＩ明显增高，血粘度中之高切粘度、低切粘度及血浆凝血因子Ｉ明显降低（Ｐ＜０．０５～０．０１），而ＴＣ，ＴＧ，ＨＤＬ＿ｃｈ，ＡｐｏＢ及血细胞比容、血沉等差别无显著意义（Ｐ＞０．０５）。结论：尼尔雌醇可作为绝经后妇女高脂血症及高粘综合征治疗的有效药物之一。 Objective: To observe the effect of nilestriol on the blood lipids and hemorheology in postmenopausal women. Methods: Thirty women with postmenopausal period were given oral nylestriol 5 mg once a month for 3 months. Blood lipid and blood rheology were measured before and after taking the medicine. Results: LDL_ch and LDL_ch / HDL_ch decreased significantly compared with those before treatment, and ApoAI increased significantly. High shear viscosity, low shear viscosity and plasma coagulation factor I in blood viscosity decreased significantly (P <0.05-0.01) TG, HDL_ch, ApoB and hematocrit, erythrocyte sedimentation rate were not significantly different (P> 0.05). Conclusion: Nilestriol can be used as one of the effective drugs for the treatment of hyperlipidemia and hyperviscosity syndrome in postmenopausal women.