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目的探讨特布他林联合糖皮质激素治疗慢性阻塞性肺疾病(COPD)急性加重期的疗效。方法选取2011—2012年安新县医院收治的COPD急性加重期患者112例,随机分为观察组与对照组,各56例。对照组患者予以特布他林治疗,观察组患者在对照组基础上加用糖皮质激素治疗。观察两组患者动脉血气指标、临床疗效及呼吸困难分级。结果治疗前两组患者Pa O2、Pa CO2和p H值比较,差异无统计学意义(P>0.05),治疗后观察组患者Pa O2和p H值高于对照组,Pa CO2低于对照组,差异有统计学意义(P<0.05);观察组患者临床疗效优于对照组(P<0.05);治疗前两组患者呼吸困难分级比较,差异无统计学意义(P>0.05),治疗后观察组患者呼吸困难分级优于对照组(P<0.05)。结论特布他林联合糖皮质激素治疗COPD急性加重期的疗效显著,可改善患者临床症状,提高生活质量。
Objective To investigate the efficacy of terbutaline combined with glucocorticoid in the treatment of acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods One hundred and twelve patients with acute exacerbation of COPD admitted in Anxin County Hospital from 2011 to 2012 were randomly divided into observation group and control group, with 56 cases in each group. Patients in the control group were treated with terbutaline. Patients in the observation group were treated with glucocorticoid on the basis of the control group. Arterial blood gas indexes, clinical efficacy and dyspnea classification were observed in two groups. Results There was no significant difference in the values of Pa O2, Pa CO2 and p H between the two groups before treatment (P> 0.05). After treatment, Pa O2 and p H values in observation group were higher than those in control group and Pa CO2 was lower than that in control group , The difference was statistically significant (P <0.05). The clinical curative effect in the observation group was better than that in the control group (P <0.05). There was no significant difference in the classification of dyspnea between the two groups before treatment (P> 0.05) The observation group had better respiratory distress classification than the control group (P <0.05). Conclusion Terbutaline combined with glucocorticoid treatment of acute exacerbation of COPD significant effect, can improve clinical symptoms and improve quality of life.