1978年 Tan EM 等在研究细胞增殖周期时发现,含有抗自身抗体的少数系统性红斑狼疮病人的血清,可与增殖细胞的胞核发生免疫荧光反应,这种反应不同于组蛋白、DNA 聚合酶、引物酶等已知的核内蛋白或酶的免疫反应,并且其荧光图像随细胞周期而变化,他们将这种独具特征的蛋白质称为 In 1978, Tan EM et al. Found that the serum of a small number of patients with systemic lupus erythematosus that contain anti-autoantibodies can be immunofluorescently reacted with the nucleus of proliferating cells during the study of the cell cycle. This reaction is different from that of histones, DNA polymerase , A known enzyme such as a nuclear enzyme enzyme or enzyme immune response, and its fluorescence image changes with the cell cycle, they will this unique protein called