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目的 观察单一ＴＴＶ 感染患者肝组织学特征．方法 对某职业学校ＴＴＶ 感染流行期间１８ 例住院患者行肝活检组织检查，其中９ 例行电镜观察．结果 在肝穿刺标本１８ 例中，出现汇管区炎１４ 例（７７－８ ％ ） ，胆小管损害６ 例（３３－４ ％ ） ，肝小叶内灶状坏死７ 例（３８－９ ％ ） ，小泡性脂肪变（ 微脂滴）３ 例（１６－７ ％ ） ，汇管区纤维化２ 例（１１－１ ％ ） ． 电镜提示线粒体肿胀和溶酶体增加，未见病毒颗粒．结论 单一ＴＴＶ 感染可致患者肝组织轻度炎性病变，其特征是汇管区炎为主，部分伴胆小管损害．
Objective To observe the liver histological features of a single TTV infection. Methods Twenty-eight inpatients undergoing TTV infection in a vocational school were examined by liver biopsy, of which 9 were examined by electron microscopy. Results Among the 18 cases of liver biopsy, 14 cases (77-8%) had cholangitis, 6 cases (33-4%) had cholangiocarcinoma, 7 (38-9%) hepatic lobules with focal necrosis, Three cases (16-7%) had vesicular steatosis (micro-lipid droplets) and two cases (11-1%) had portal fibrosis. Electron microscopy prompted mitochondrial swelling and lysosome increased, no virus particles. Conclusion A single TTV infection can cause mild inflammatory lesions in patients with liver, which is characterized by inflammation in the portal area, and some with tubule damage.