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目的探讨三甲基氯化锡中毒并发心律失常的发病机制及其临床意义。方法对387例三甲基氯化锡中毒并发心律失常患者心电图相关资料进行回顾性分析。结果三甲基氯化锡中毒并发心律失常发生率为41.9%,严重中毒患者易并发心律失常,与患者中毒途径、时间有一定关联。患者可有不同程度的出现心律失常,主要表现为窦性心动过速、窦性心动过缓、室性早搏、ST-T改变等。结论三甲基氯化锡致心律失常可能与低钾、窦房结及心肌异位兴奋性增高或中毒性心肌炎有关,其发生机制值得进一步研究。
Objective To investigate the pathogenesis and clinical significance of trimethyltin chloride poisoning complicated with arrhythmia. Methods 387 cases of trimethyltin poisoning complicated by arrhythmia patients ECG data were retrospectively analyzed. Results The incidence of arrhythmia of trimethyltin chloride poisoning was 41.9%. Patients with severe poisoning were more likely to have arrhythmia, which was related to the path and time of poisoning. Patients may have varying degrees of arrhythmia, mainly as sinus tachycardia, sinus bradycardia, ventricular premature beats, ST-T changes. Conclusion Trimethytin chloride induced arrhythmia may be related to hypokalemia, sinus node and abnormal ectopic excitability or toxic myocarditis, and its mechanism deserves further study.