自1962年发现第一个喹诺酮类抗菌药并用于临床以来,经过30余年的发展,它已成为一大类广泛用于治疗各种感染性疾病的广谱、高效、低毒性的化疗药物。目前全世界从事该药物研究的单位超过100所,已合成的喹诺酮化合物近10万个。特别是各国药物工作者研制的第三代喹诺酮类药物,其抗 Since its discovery of the first quinolone antibiotic in 1962 for clinical use, it has become a broad class of broad-spectrum, high-potency, low-toxicity chemotherapeutic drugs that are widely used to treat various infectious diseases after more than 30 years of development. At present, there are more than 100 units engaged in the research of this drug in the world and about 100,000 quinolone compounds have been synthesized. In particular, the third-generation quinolone drugs developed by drug workers in various countries have their resistance