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目的比较无创式机械通气与有创式机械通气治疗重症肌无力危象的临床效果。方法回顾性分析我院2005年1月-2010年11月就诊的23例重症肌无力危象患者的临床资料,采用有创式机械通气治疗的11例作为对照组,采用无创式机械通气治疗的12例作为观察组,比较两组的临床应用情况。结果两组治疗后1、24 h患者的血气分析、呼吸频率以及心率均趋于正常(P<0.05),但两组间差异无统计学意义(P>0.05);观察组的并发症发生率及抗生素使用率均明显低于对照组,组间差异有统计学意义(P<0.05)。结论无创式机械通气治疗重症肌无力危象能够避免气管插管,且减少了并发症的发生和抗生素的使用,值得临床关注。
Objective To compare the clinical effects of noninvasive mechanical ventilation and invasive mechanical ventilation in the treatment of myasthenia gravis crisis. Methods The clinical data of 23 patients with myasthenia gravis crisis who were treated in our hospital from January 2005 to November 2010 were analyzed retrospectively. Eleven patients with invasive mechanical ventilation were used as control group and were treated with non-invasive mechanical ventilation Twelve cases were used as the observation group to compare the clinical application of the two groups. Results The blood gas analysis, respiration rate and heart rate of the two groups at 1 and 24 h after treatment were all normal (P <0.05), but there was no significant difference between the two groups (P> 0.05). The complication rate And antibiotics utilization rate were significantly lower than the control group, the difference between the groups was statistically significant (P <0.05). Conclusion Noninvasive mechanical ventilation in the treatment of myasthenia gravis crisis can avoid endotracheal intubation, and reduce the incidence of complications and the use of antibiotics, deserves clinical attention.