AIM:To study the expression of CDw75 in patients withgastric carcinoma and to correlate CDw75 expression withprogression of the tumor.METHODS:Immunohistochemical method was used toexamine the expression of CDw75 in 72 cases of the gastriccarcinoma and adjacent normal gastric mucosa,and thepercentage of the cells positively stained with CDw75 wascalculated using a computer-aided microscopic imageanalysis system.RESULTS:CDw75 was not expressed in normal gastricmucosa but detected in 37 of the 72 neoplastic gastriclesions.The expression of CDw75 was associated with thetumor progression as indicated by its close correlation withthe depth of the tumor infiltration (X~2=18.415,P<0.01),TNM stage (X~2=10.419,P<0.05) and lymph node metastasis(X~2=6.675,P<0.01).The overall survival rate of the patientswith positive CDw75 expression (32.4%) was significantlylower than that of the patients without CDw75 expression(71.4%) (P<0.01).There was no significant correlationbetween the expression of CDw75 and the sex and ageand histological type of patients (P>0.05).CONCLUSION:These findings suggest that the expressionof CDw75 is a significant histopathological marker for moreadvanced stage of gastric carcinoma and indicates a poorprognosis for the patients. AIM: To study the expression of CDw75 in patients with gastric carcinoma and to correlate CDw75 expression withprogression of the tumor. METHODS: Immunohistochemical method was used toexamine the expression of CDw75 in 72 cases of the gastriccarcinoma and adjacent normal gastric mucosa, and the percentage of the cells positively stained with CDw75 wascalculated using a computer-aided microscopic imageanalysis system .RESULTS: CDw75 was not expressed in normal gastric mucosa but detected in 37 of the 72 neoplastic gastriclesions. The expression of CDw75 was associated with the tumor progression as indicated by its close correlation with the depth of the tumor infiltration (X ~ 2 = 18.415, P <0.01) .The TNM stage (X ~ 2 = 10.419, P <0.05) and the lymph node metastasis the patients with positive CDw75 expression (32.4%) were significantly lower than those of the patients without CDw75 expression (71.4%) (P <0.01). There was no significant correlation between the expression of CDw75 and the sex and age and histological type of patients (P> 0.05). CONCLUSION: These findings suggest that the expression of CDw75 is a significant histopathological marker for more advanced stage of gastric carcinoma and indicates a poor prognosis for the patients.