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本文报道了24年间连续收治的11例恶性贫血的临床、实验室工作、治疗和随访的后果。11例恶性贫血占同期各种贫血的2%,其主要症状除贫血外为神经系统和胃部症状,贫血表现为巨幼红细胞贫血,胃液无盐酸。5例经胃镜检查,3例呈典型之慢性萎缩性胃炎病变。6例检查了壁细胞抗体,其中5例阳性,用Vit B_(12)治疗后,均获迅速和良好效果。随访9例,除2例因高龄死于无关疾病外,余均健在。其中有2人因停止治疗1—2年后,又有复发,再次用Vit B治疗,又迅速恢复。作者等认为本病并非十分罕见,应多提高警惕性。
This article reports the results of clinical, laboratory work, treatment, and follow-up of 11 consecutive cases of pernicious anemia over a 24-year period. 11 cases of pernicious anemia accounted for 2% of all kinds of anemia in the same period, the main symptoms except for anemia were nervous system and stomach symptoms, anemia showed megaloblastic anemia, gastric juice without hydrochloric acid. 5 cases of gastroscopy, 3 cases of typical chronic atrophic gastritis lesions. 6 cases of parietal cell antibodies were examined, of which 5 were positive, with Vit B_ (12) treatment, were rapid and good results. All the patients were followed up for 9 years. Except for 2 cases of age-related death from unrelated diseases, Yu Jun was alive. Two of them stopped relapse after 1-2 years of treatment and were again treated with Vit B and recovered quickly. The authors believe that the disease is not very rare, should be increased vigilance.