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随着基因组测序成本快速下降,许多医生开始根据对肿瘤的基因检测结果来治疗癌症患者。但美国研究人员15日警告说,这种检测会具有误导性,约一半癌症患者的治疗可能不会有效果。这项发表在美国《科学转化医学》杂志上的研究报告解释说,癌症患者肿瘤中的许多基因突变实际上与癌症并无关联,它们是所谓的生殖系突变,即从父母那里遗传而来,正常组织中也有这些突变,不过每个人的这种突变都不相同。
As the cost of sequencing genomes drops rapidly, many doctors begin to treat cancer patients based on genetic testing of tumors. However, U.S. researchers warned on the 15th that the test would be misleading and about half the treatment of cancer patients may not be effective. The study, published in the journal Science Translational Medicine in the United States, explains that many of the genetic mutations in cancer patients’ cancers are virtually unrelated to cancer, the so-called germline mutations that are inherited from their parents, These mutations are also found in normal tissues, but each person’s mutation is different.