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目的对男性类风湿关节炎患者血清雌雄性激素比例变化及临床意义进行分析探讨,为今后的临床诊治工作提供可靠的参考依据。方法抽取本院收治的临床确诊男性类风湿关节炎患者56例和同期健康体检者60例,对其展开性激素水平检测,并对检测结果进行对比分析。结果类风湿关节炎组患者血清睾酮、硫酸脱氢表雄酮水平较健康对照组发生显著降低(P<0.05),雌二醇水平同样低于健康对照组,但差异无统计学意义(P>0.05)。结论类风湿关节炎患者的性激素水平发生了明显的改变,这对于临床诊治工作而言意义重大,值得关注。
Objective To analyze and discuss the change of serum androgen ratio in patients with rheumatoid arthritis and to provide a reliable reference for future clinical diagnosis and treatment. Methods Fifty-six patients with clinically diagnosed rheumatoid arthritis and 60 healthy subjects at the same period were enrolled in this study. The levels of sex hormones were measured and the results were compared. Results The levels of serum testosterone and dehydroepiandrosterone in patients with rheumatoid arthritis were significantly lower than those in healthy controls (P <0.05), and the levels of estradiol in patients with rheumatoid arthritis were also lower than those in healthy controls (P> 0.05). Conclusions The level of sex hormones in patients with rheumatoid arthritis has undergone significant changes, which is of great significance for clinical diagnosis and treatment, which deserves our attention.