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目的探讨儿童亚急性坏死性淋巴结炎(SNL)的病因及临床特征和治疗方法,提高对儿童SNL的认识,减少误诊误治。方法对SNL患儿38例临床及实验室相关检查进行回顾分析。结果本组38例患儿淋巴结活检确诊SNL;发病以学龄儿为主,患儿发病无季节性,男女之比1.1:1,38例淋巴结大及发热,30例白细胞总数减少;其中1例发展为SLE,2例复发。结论对不明原因长期发热伴淋巴结大者,应早期行淋巴结活检以明确诊断;手术取受累最大淋巴结,可作为一种诊断性治疗;SNL是自限性疾病,预后多良好,但少数也有复发或发展SLE,应长期规律随访。
Objective To investigate the etiology, clinical features and treatment of sub-acute necrotizing lymphadenitis (SNL) in children and to raise awareness of SNL in children and reduce misdiagnosis and mistreatment. Methods The clinical and laboratory related tests of 38 children with SNL were retrospectively analyzed. Results The lymph node biopsy of 38 children was diagnosed as SNL. The incidence was mainly in school-age children. There was no seasonal incidence in children. The ratio of men to women was 1.1: 1 in 38 cases with lymph nodes and fever, and the total number of 30 leukocytes decreased. One case developed For SLE, 2 patients relapsed. Conclusions Lymph node biopsy should be conducted early to confirm the diagnosis of long-term fever with unknown lymph node. Long-term lymph node biopsy should be done early to confirm the diagnosis. The largest lymph node involvement can be used as a diagnostic treatment. SNL is a self-limiting disease with good prognosis. However, The development of SLE, should be regular follow-up.