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目的 :观察小剂量短疗程格拉诺赛特用于恶性肿瘤患者化疗后改善白细胞减少状况的疗效。方法 :5 6例肿瘤患者 (设自身对照 )于常规化疗后 ,应用小剂量短疗程格拉诺赛特 (5 0 μg/天 ,3～ 4天 )皮下注射 ,并观察血象变化。结果 :治疗组白细胞减少的天数为 7.2天 (平均 ) ,最低值为 2 .15× 10 9/L ;对照组为 2 0天 (P =0 .0 2 5 )和1.19× 10 9/L(P >0 .0 5 )。结论 :小剂量短疗程格拉诺赛特的应用可缩短骨髓造血恢复时间 ,减少白细胞降低天数 ,但是不能改善白细胞降低的幅度
Objective: To observe the efficacy of low-dose short-course Granoside treatment for leukopenia after chemotherapy in patients with malignant tumors. METHODS: A total of 56 patients with cancer (with self-control) were treated with conventional low-dose Granosite (50 μg/day, 3 to 4 days) after routine chemotherapy, and blood changes were observed. Results: The days of leukopenia in the treatment group were 7.2 days (average), the lowest was 2.15×10 9 /L; the control group was 20 days (P =0.05 5) and 1.19×10 9 /L ( P >0 .0 5 ). Conclusion: The use of low-dose, short-course Granosite can shorten the recovery time of bone marrow hematopoiesis and decrease the days of leukocyte decrease, but it can not improve the decrease of leukocyte.