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滤泡辅助性T(Tfh)细胞是一群定位于淋巴滤泡的辅助性T细胞,表型为CD4+CXCR5+ICOS+PD1+,是主要负责辅助B细胞产生抗体的T细胞亚群。多种转录因子对初始T淋巴细胞向各亚群细胞分化至关重要,包括B细胞淋巴瘤因子6(Bcl-6)、淋巴增强结合因子1(LEF-1)、T细胞因子1(TCF-1)、活化性T细胞的核因子(NFAT)、无刚毛鳞甲复合体同源物2(Ascl2)、干扰素调节因子4(IRF4)、细胞肌腱膜纤维肉瘤因子(c-Maf)、B淋巴细胞诱导成熟蛋白1(Blimp1)、碱性亮氨酸拉链转录因子ATF样蛋白(BATF)和信号转导与转录激活子(STAT)等。
Follicular helper T (Tfh) cells are a group of helper T cells localized in lymphoid follicles with a phenotype of CD4 + CXCR5 + ICOS + PD1 +, a subset of T cells that are primarily responsible for assisting B cells in producing antibodies. A variety of transcription factors are crucial for the differentiation of naive T lymphocytes into various subpopulations including Bcl-6, LEF-1, TCF- 1), NFAT, Ascl2, IRF4, c-Maf, B Lymphocyte-induced mature protein 1 (Blimp1), alkaline leucine zipper transcription factor ATF-like protein (BATF) and signal transducers and activators of transcription (STAT).