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目的 :用Amplisensor定量PCR技术考核短期静脉注射膦甲酸钠治疗慢性乙型肝炎的疗效 ,为膦甲酸钠治疗乙型肝炎的临床推广应用提供科学依据。方法 :选择 2 2例慢性乙型肝炎患者 ,给予膦甲酸钠 2 .4g ,加入5 %葡萄糖液 10 0ml稀释后静脉滴注 ,bid ,用 2 8d ,同时用常规护肝药物 ;对照组 10例仅给予常规护肝药物共 2 8d。检测治疗前后患者血清HBV DNA水平、乙肝三系和肝功能的变化情况。结果 :试验组 2 2例患者中有 14例血清HBV DNA水平在治疗结束时有不同程度的下降 ,平均值 (对数值 )由 7.6 0± 1.41下降为 6 .89± 1.2 8(P <0 .0 5 ) ;12例HBeAg阳性患者中有 3例阴转。对照组 10例患者中有 7例HBV DNA水平下降 ,平均值 (对数值 )由 8.5 0±0 .81下降为 8.2 8± 0 .91(P >0 .0 5 ) ;7例HBeAg阳性患者中无 1例阴转。试验组和对照组之间ALT和T Bil的变化无明显差异。在治疗过程中未发现明显的不良反应。结论 :短期静脉注射膦甲酸钠用于治疗慢性乙型肝炎 ,对抑制乙肝病毒复制具有一定的作用 ,其远期疗效尚待进一步研究。
Objective: To evaluate the efficacy of short-term intravenous injection of foscarnet in the treatment of chronic hepatitis B by Amplisensor quantitative PCR and to provide a scientific basis for the clinical application of foscarnet in the treatment of hepatitis B. Methods: Twenty-two patients with chronic hepatitis B were selected and administered with 2.4 g of sodium foscarnet and 10 0 ml of 5% dextrose solution for intravenous instillation. The patients were treated with conventional hepatoprotective drugs for 28 days, while the control group of 10 patients Give regular liver drug a total of 2 8d. Pre and post-treatment serum HBV DNA levels, hepatitis B three lines and liver function changes. Results: Serum HBV DNA levels of 14 out of 22 patients in the experimental group decreased to some extent at the end of treatment, and the mean value (logarithm) decreased from 7.6 0 ± 1.41 to 6.89 ± 1.2 8 (P <0. 0 5); 3 of 12 HBeAg-positive patients were negative. HBV DNA levels decreased in 7 of 10 patients in the control group, and the mean (logarithmic value) decreased from 8.5 0 ± 0.81 to 8.2 8 ± 0.91 (P> 0.05). Among 7 HBeAg-positive patients No case of overcast. There was no significant difference in ALT and T Bil between the experimental group and the control group. No significant adverse reactions were found during treatment. Conclusion: Short-term intravenous injection of foscarnet for the treatment of chronic hepatitis B has a certain effect on the inhibition of hepatitis B virus replication. The long-term therapeutic effect remains to be further studied.