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目的 观察半剂量静脉丙种球蛋白(IVIG)联合长春新碱(VCR)治疗重症新诊断原发免疫性血小板减少症(ITP)的疗效.方法 选择2010年9月-2014年9月医院收治的重症ITP患者24例,随机分为2组各12例,A组给予半剂量IVIG联合VCR治疗.B组给予IVIG治疗.2组均同时联合常规剂量糖皮质激素治疗.比较2组疗效.结果 治疗前2组PLT水平比较差异无统计学意义(P>0.05),治疗后3、7、14、28、90 d 2组PLT均升高(P0.05).随访2年A组PLT水平高于B组(P0.05).随访2年A组基本治愈率高于B组,差异有统计学意义(P0.05).The level of PLT on 3,7,14,28,90 days after treatment of 2 groups were higher than that before treatment(P0.05).Follow up for 2 years,the level of PLT in group A was higher than that in group B(P0.05).Follow up for 2 years,The basic cure rate of group A was higher than that of group B,the difference was statistically significant(P<0.05).Conclusion Half dose intravenous gamma globulin(IVIG) and vincristine(VCR) in severe new diagnosis of primary immune thrombocytopenia(ITP)has an good effect,worthy of clinial application.