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目的观察分析盐酸氨基葡萄糖片治疗类风湿关节炎致膝软骨损伤的临床疗效。方法选取2011年1月-2015年1月期间收治的类风湿关节炎致膝软骨损伤患者200例作为研究对象,按入院时间的不同,分为对照组(n=98)和研究组(n=102),对照组给予常规缓解病情抗风湿药物(DMARD)治疗,研究组在此基础上加用盐酸氨基葡萄糖片治疗,分别于治疗18、36、54周后,对两组患者的治疗效果进行评定。结果治疗54周后,研究组膝关节疼痛评分显示治疗效果明显优于对照组,差异有统计学意义(P<0.05);研究组治疗后的Noyes评价水平低于对照组,差异有统计学意义(P<0.05);研究组不良反应发生率为3.92%,对照组不良反应发生率为3.06%,两组差异无统计学意义(P>0.05)。结论盐酸氨基葡萄糖片联合DMARD治疗类风湿关节炎致膝软骨损伤临床有效,可促进软骨修复,值得临床使用。
Objective To observe the clinical effect of glucosamine hydrochloride tablets in the treatment of knee joint cartilage injury induced by rheumatoid arthritis. Methods 200 patients with knee osteoarthritis caused by rheumatoid arthritis were selected from January 2011 to January 2015. The patients were divided into control group (n = 98) and study group (n = 102). The control group was treated with routine antidiabetic drug (DMARD). The study group was treated with glucosamine hydrochloride tablets on the basis of this study. After 18, 36, and 54 weeks of treatment, the treatment effect was compared between the two groups assessment. Results After 54 weeks of treatment, the knee pain scores of the study group were significantly better than those of the control group (P <0.05). The Noyes score of the study group after treatment was lower than that of the control group (P <0.05). The adverse reaction rate was 3.92% in the study group and 3.06% in the control group. There was no significant difference between the two groups (P> 0.05). Conclusion Glucosamine hydrochloride tablets combined with DMARD in the treatment of rheumatoid arthritis of knee cartilage injury is clinically effective and can promote cartilage repair, worthy of clinical use.