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选择三水合亚铁氰化钾作为内标物,定量添加到抗坏血酸中,在抗坏血酸质量分数为1%～10%范围内,测得混合物红外光谱中抗坏血酸的测量峰(1 754.1 cm-1)和三水合亚铁氰化钾的内标峰(2 092.7 cm-1)的峰高比(y=hi/hs)与两者质量比(x=mi/ms)有良好的线性关系,其线性回归方程为y=0.566 3x+0.110 4,相关系数r=0.998 6。据此测得维C银翘片和维生素C片样品中抗坏血酸的含量分别为25.8%和72.4%,相对标准偏差为0.7%和0.6%,加标回收率分别为98.1%～106.3%和98.7%～102.7%,测定结果与药典规定的碘量法相近。该法消耗样品少,选择性高,测定结果准确,有应用价值。
The potassium ferrocyanide trihydrate was selected as the internal standard and was quantitatively added to ascorbic acid. The measured peak of ascorbic acid (1 754.1 cm -1) in the infrared spectrum of the mixture was measured in the range of 1% -10% ascorbic acid The peak height ratio (y = hi / hs) of the internal standard peak of ferrous potassium ferrocyanide (2 092.7 cm-1) and its mass ratio (x = mi / ms) have a good linear relationship, The equation is y = 0.566 3x + 0.110 4, the correlation coefficient r = 0.998 6. The results showed that the content of ascorbic acid in Vitamin C Yinqiao tablets and Vitamin C tablets were 25.8% and 72.4%, the relative standard deviations were 0.7% and 0.6%, and the recoveries were 98.1% -106.3% and 98.7% respectively ~ 102.7%, the determination of the results and Pharmacopoeia Iodine approach similar. The law consumes less samples, high selectivity, accurate determination of the results, there is application value.