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目的:探讨中药对糖尿病大鼠肾脏保护作用及作用机制。方法:以STZ诱导的糖尿病大鼠模型,观察止消通脉宁对糖尿病大鼠肾功能及肾脏病理的影响。结果:该药可降低糖尿病大鼠肾小球高滤过、控制肾脏肥大、减少尿蛋白、减轻肾小球系膜基质增生及毛细血管基底膜增厚。
Objective: To investigate the protective effect and mechanism of traditional Chinese medicine on kidney in diabetic rats. Methods: The effects of Zhixiao Tongmaining on renal function and renal pathology in diabetic rats were observed with STZ-induced diabetic rats. Results: The drug can reduce glomerular hyperfiltration in diabetic rats, control kidney hypertrophy, reduce urinary protein, reduce mesangial matrix proliferation and capillary basement membrane thickening.