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应用弹性蛋白酶气管内滴入复制金黄地鼠肺气肿模型。方法：将金黄地鼠麻醉后，气管内一次性滴入弹性蛋白酶液（４０ ｕ／１００ ｇ体重），分别于实验第 ３天、１周、２周、３周、４周时处死。对地鼠肺脏进行病理学检查，测定第４周时平均肺动脉压、右室收缩压、右心室肥大指数、肺容积。结果：实验第４周时，地鼠出现了典型的肺气肿改变，平均肺动脉压、右室收缩压、右心室肥大指数、肺容积均明显高于对照组（Ｐ＜０．０５或Ｐ＜０．０１）。结论：气管内一次性滴入弹性蛋白酶可成功地复制出金黄地鼠肺气肿模型。
Application of Elastase Intratracheal Instillation of Golden Hamster Emphysema Model. Methods: After the hamster was anesthetized, the elastase solution (40 u / 100 g body weight) was instilled in the trachea once a day for three weeks, one week, two weeks, three weeks and four weeks respectively. Pathological examination was performed on the hamster lungs. Mean pulmonary artery pressure, right ventricular systolic pressure, right ventricular hypertrophy index, and lung volume at 4 weeks were measured. Results: At the 4th week of the experiment, typical changes of emphysema appeared in the rats. The average pulmonary arterial pressure, right ventricular systolic pressure, right ventricular hypertrophy index and lung volume were significantly higher than those in the control group (P <0.05 or P < 0.01). Conclusion: Intraperitoneal instillation of elastase can successfully replicate golden hamster emphysema model.