质子泵抑制剂对PCI术后双联抗血小板治疗所致上消化道出血的影响

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目的 探讨质子泵抑制剂对PCI术后双联抗血小板治疗所致上消化道出血的影响.方法 选择冠状动脉粥样硬化性心脏病并接受PCI治疗的患者218例,随机分为观察组与对照组.观察组在阿司匹林+氯吡格雷抗血小板治疗的基础上联合口服埃索美拉唑治疗,比较2组患者血小板聚集率、上消化道出血和支架内血栓形成的发生率.结果 2组患者PCI术前及术后12周比较血小板聚集率均无显著差异(P>0.05);术后随访12月,观察组无上消化道出血发生,对照组发生率为3.67%,差异有统计学意义(P<0.05);观察组支架内血栓形成2例(1
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