Objective:To predict preoperative staging using a radiomics approach based on computed tomography (CT)images of patients with esophageal squamous cell carcinoma (ESCC).Methods:This retrospective study included 154 patients (primary cohort:n=114;validation cohort:n=40) with pathologically confirmed ESCC.All patients underwent a preoperative CT scan from the neck to abdomen.High throughput and quantitative radiomics features were extracted from the CT images for each patient.A radiomics signature was constructed using the least absolute shrinkage and selection operator (Lasso).Associations between radiomics signature,tumor volume and ESCC staging were explored.Diagnostic performance of radiomics approach and tumor volume for discriminating between stages Ⅰ-Ⅱ and Ⅲ-Ⅳ was evaluated and compared using the receiver operating characteristics (ROC) curves and net reclassification improvement (NRI).Results:A total of 9,790 radiomics features were extracted.Ten features were selected to build a radiomics signature after feature dimension reduction.The radiomics signature was significantly associated with ESCC staging (P＜0.001),and yielded a better performance for discrimination of early and advanced stage ESCC compared to tumor volume in both the primary [area under the receiver operating characteristic curve (AUC):0.795 vs.0.694,P=0.003;NRI--0.424)] and validation cohorts (AUC:0.762 vs.0.624,P=0.035;NRI=0.834).Conclusions:The quantitative approach has the potential to identify stage Ⅰ-Ⅱ and Ⅲ-Ⅳ ESCC before treatment.