论文部分内容阅读
目的探索外周血白细胞表达的CD64水平结合脂蛋白A[LP(a)]、C反应蛋白(CRP)、中性粒细胞碱性磷酸酶(NAP)积分3种指标对鉴别发热是否诊断为細菌感染的意义。方法对发热患者进行分组,在治疗前均进行外周血病原学培养(或根据病情需要同时取骨髓病原学培养),并取其外周血用流式细胞术检测白细胞表达的CD64水平,同时检测LP(a)、CRP、NAP积分。对于病原学培养阳性的52例患者,收集其上述指标的結果,综合分析观察細菌感染的患者上述指标的变化情況。结果细菌感染引起的发热将导致CD64、LP(a)、CRP、NAP积分明显升高,部分非感染因素引起的发热病例CRP、NAP积分可能升高,但CD64及LP(a)均无明显升高。结论CD64可作为鉴别細菌性感染及其他非感染性发热的參考指标,结合LP(a)、CRP、NAP积分等其他指标将有助于对发热的原因进行分析。
Objective To explore whether CD64 level in peripheral blood leucocytes combined with lipoprotein A [LP (a)], C-reactive protein (CRP) and neutrophil alkaline phosphatase (NAP) Meaning. Methods The patients with fever were divided into groups and were treated with peripheral blood etiology (or bone marrow elicitation according to their condition) before treatment. The peripheral blood was collected to detect the level of CD64 in leukocytes by flow cytometry. (a), CRP, NAP points. 52 patients with positive etiological culture collected the results of the above indicators, a comprehensive analysis of changes in bacterial infection in patients with the above indicators. Results The fever caused by bacterial infection led to a significant increase of CD64, LP (a), CRP and NAP scores. Some non-infection-induced febrile patients had elevated CRP and NAP scores but no significant increase in CD64 and LP (a) high. Conclusion CD64 can be used as a reference index to identify bacterial infection and other non-infectious fever. Combined with other indicators such as LP (a), CRP and NAP, it will be helpful to analyze the causes of fever.