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目的分析长托宁治疗急性重度有机磷中毒的临床疗效。方法 110例急性重度有机磷中毒患者,根据治疗时所采用治疗方案不同分为对照组(50例)和研究组(60例)。对照组患者行阿托品治疗,研究组患者行长托宁治疗。比较两组临床疗效及基础指标。结果研究组治疗总有效率为96.67%,显著高于对照组的42.00%,且研究组给药次数、胆碱酯酶(CHE)恢复时间均显著优于对照组,差异均有统计学意义(P<0.05)。结论长托宁治疗急性重度有机磷中毒的临床疗效显著,值得临床推广。
Objective To analyze the clinical efficacy of penehyclidine hydrochloride in the treatment of acute severe organophosphate poisoning. Methods One hundred and ten patients with acute severe organophosphate poisoning were divided into control group (n = 50) and study group (n = 60) according to the different treatment regimens. Patients in the control group underwent atropine treatment and study group patients were treated with tetralone. The clinical curative effect and basic index of the two groups were compared. Results The total effective rate of the study group was 96.67%, which was significantly higher than that of the control group (42.00%). The number of administration and the recovery time of cholinesterase (CHE) in the study group were significantly better than those in the control group P <0.05). Conclusion Long-tingling treatment of acute severe organophosphate poisoning has a significant clinical effect, worthy of clinical promotion.