Plastics are ubiquitous.Their role as a cost-effective, chemically stable, versatile multipurpose material precluded early attempts to regulate plastic wastes and facilitated the, now widespread, planetary contamination.Left to slow UV decay and thermooxidative weathering, large plastics chip away into less than 5 mm fragments, or microplastics, which, in turn, can degrade further into nanoplastics.In the manufacturing process, several components, such as catalysts, solvents, stabilizers, flame-retardants or pigments, can be added to the nascent plastic polymers.During the plastic break down, these additives, some of which act as disruptors of endocrine pathways, may liberate to the surrounding medium, worsening the effects of plastic pollution [1].All this wear and tear provide attachment surfaces for microorganisms, including pathogens, enhances the incorporation of plastic fragments into marine and terrestrial food webs, and, once bioaccumulated, may impair endogenous endocrine and neuroimmune crosstalk in vertebrates and invertebrates (Fig.1).