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新生儿窒息是新生儿常见急症之一,严重威胁小婴儿的健康和生命,复苏后积极有效的处理,对预防窒息后新生儿出现的并发症及改善预后有重要意义。本文总结我院60例新生儿窒息患儿早期应用负荷量苯巴比妥治疗的疗效,现报道如下。 1 资料及方法 1.1 一般资料 系1995年3月至1998年6月收住我院的新生儿窒息患儿120例,生后5分钟至6小时入院。诊断依据及临床分度均根据诸福棠第6版《实用儿科学》制定的标准。根据治疗方法不同随机分为两组,治疗组和对照组各60例,两组患儿均为足月儿,在性别、出生体重、窒息程度等方面比较,均无显著性差异。 1.2 临床表现 两组意识障碍程度、肌张力及原始反射改变等情况均无显著性差异。临床分度比较,治疗组60例,轻度窒息36例(60％),重度窒息24例(40％);对照组轻度窒息37例(61.7％),重度窒息23例(38.3％)。 1.3 治疗方法 两组患儿均给予吸氧、纠酸、注意保暖、防治感染、支持治疗、对症治疗,如控制惊厥和降低颅内压,以及应用脑细胞代谢药物等,治疗组在此基础上于入院后即刻给苯巴比妥负荷量20～30mg/kg肌注,然后再予维持量每天3～5mg/kg,共5天。
Asphyxia neonatorum is one of the most common neonatal emergencies, a serious threat to the health and life of small infants, the recovery after the active and effective treatment of neonatal complications after asphyxia and improve prognosis of great significance. This article summarizes the 60 cases of neonatal asphyxia in our hospital early application of phenobarbital load effect, are reported below. 1 Materials and Methods 1.1 General Information Department of March 1995 to June 1998 admitted to our hospital 120 cases of neonatal asphyxia in children, after birth, 5 minutes to 6 hours admitted. The basis for diagnosis and clinical sub-standard are based on the fourth edition of Fu Tong Tang “Practical Pediatrics” developed standards. According to the different treatment methods, the patients were randomly divided into two groups. The treatment group and control group had 60 cases each. All the children in the two groups were full-term children. There was no significant difference in gender, birth weight and degree of asphyxia. 1.2 Clinical manifestations of two groups of disturbance of consciousness, muscle tone and the original reflex changes were not significantly different. There were 60 cases in the treatment group, 36 cases (60%) in mild asphyxia and 24 cases (40%) in severe asphyxia. The control group had mild asphyxia in 37 cases (61.7%) and severe asphyxia in 23 cases (38.3%). 1.3 Treatment Two groups of children were given oxygen, correcting acid, keep warm, prevent infection, supportive treatment, symptomatic treatment, such as control of seizures and reduce intracranial pressure, and the application of brain cell metabolism drugs, the treatment group on this basis Immediately after admission to the phenobarbital load 20 ~ 30mg / kg intramuscular injection, and then to maintain the amount of 3 ~ 5mg / kg daily for 5 days.