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近年许多报告指出,核苷酸代谢的变化可导致细胞免疫功能的损害。高浓度的腺苷可抑制免疫应答所必需的细胞分裂,从而降低细胞免疫功能。核苷酸代谢的变化可由化疗或环境改变等外部原因引起,或由与其代谢有关的酶的遗传性缺陷引起,如某些 T 细胞免疫缺陷的儿童中腺苷脱氨酶(ADA)的缺如和另一些患者中核苷磷酸化酶的缺如。免疫系统对肿瘤原位发展的防御起重要作用。故淋巴细胞中嘌呤和嘧啶浓度的任何变化,直接降低了对瘤细胞表面肿瘤抗原的免疫应答。本文即观察影响嘌呤核苷酸代谢的 ADA 与肿瘤的关系。
In recent years many reports have pointed out that changes in nucleotide metabolism can lead to impairment of cellular immune function. High concentrations of adenosine can inhibit cell division necessary for an immune response, thereby reducing cellular immune function. Changes in nucleotide metabolism can be caused by external causes such as chemotherapy or environmental changes, or by inherited defects in the enzymes involved in their metabolism, such as the absence of adenosine deaminase (ADA) in children with certain T-cell immunodeficiency Null phospholipase is absent from other patients. The immune system plays an important role in the defense of the tumor’s in situ development. Therefore, any change in purine and pyrimidine concentrations in lymphocytes directly reduces the immune response to tumor cell surface tumor antigens. This article examines the relationship between ADA and tumors that affect purine nucleotide metabolism.