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目的探讨前列腺素 E1 降低糖尿病肾病尿蛋白排泄的作用。方法 40例 2型糖尿病肾病患者随机分组 ,对照组 (2 0例 )常规口服降糖药或胰岛素治疗 ;治疗组 (2 0例 )在常规治疗的基础上给予前列腺素 E1 15 0μg加入 5 %葡葡糖液 5 0 0 ml静脉滴注 (10～ 15滴 /min) ,1次 /d,15天为一疗程。结果治疗组患者 2 4小时尿蛋白定量明显下降 ,与对照组比较有显著性差异 (P<0 .0 1) ;两组治疗前后空腹血糖均显著下降 ,组间相比无显著性差异 ;两组治疗前、后血甘油三酯、胆固醇、尿素氮、肌酐均无明显变化。结论前列腺素 E1 可降低糖尿病肾病尿蛋白的排泄
Objective To investigate the effect of prostaglandin E1 on urinary excretion of diabetic nephropathy. Methods Forty patients with type 2 diabetic nephropathy were randomly divided into two groups: the control group (20 patients) received routine oral hypoglycemic agents or insulin therapy; the treatment group (20 patients) received prostaglandin E1 150 μg plus 5% glucose Glucose 500 ml intravenous infusion (10 to 15 drops / min), 1 / d, 15 days for a course of treatment. Results In the treatment group, 24-hour urinary protein excretion was significantly decreased, compared with the control group (P <0.01); fasting blood glucose before and after treatment in both groups decreased significantly, no significant difference between the two groups; two Before treatment, blood triglycerides, cholesterol, urea nitrogen, creatinine were no significant changes. Conclusion Prostaglandin E1 can reduce urinary excretion of diabetic nephropathy