中枢神经系统(central nervous system,CNS)损伤是现代社会的高致残率疾病之一,长期以来人们普遍认为CNS一旦损伤则无法再生。近年来表皮生长因子及其受体在CNS损伤和修复中的作用越来越受到重视,并有研究发现它们通过炎症反应、活性氧生成、瘢痕形成、髓鞘脱失和神经元修复等多个因素在CNS损伤和修复中发挥重要作用。 The damage of the central nervous system (CNS) is one of the most morbid disorders in modern society. It has long been considered that CNS can not be regenerated once it has been damaged. In recent years, the role of epidermal growth factor and its receptors in the CNS injury and repair has attracted more and more attention, and many studies have found that they through a number of inflammation, reactive oxygen species generation, scarring, demyelination and neuronal repair Factors play an important role in CNS injury and repair.