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层粘连蛋白(Laminin,LN)是细胞外间质中非胶原糖蛋白的主要成分,广泛分布于基底膜的透明层中,与Ⅳ型胶原结合形成基底膜的骨架,参与影响并调节细胞的粘附、运动、生长和分化。正常情况下血清中含量较低,在肿瘤或慢性疾病等因素刺激作用下,因基底膜破损改变或机体合成加
Laminin (LN) is the main component of non-collagen glycoprotein in the extracellular matrix. It is widely distributed in the transparent layer of the basement membrane and binds to type IV collagen to form the skeleton of the basement membrane. It participates in influencing and regulating cell adhesion. Attachment, exercise, growth and differentiation. Under normal circumstances, the content of serum is low. Under the stimulating effect of tumors or chronic diseases, the basement membrane is damaged or the body synthesis is increased.