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采用亚硝酸盐间接法测定慢性肾功能衰竭患者不同病变时期和透析前后血清中一氧化氮（ＮＯ）含量的变化，并与年龄相匹配的健康人相比较。结果发现：①肾功能不全代偿期和氮质血症期患者血清ＮＯ与正常对照组无差异，而尿毒症期则明显升高；②血液透析后ＮＯ浓度较透析前明显下降。提示正常浓度的ＮＯ对肾功能起保护作用，但ＮＯ浓度的异常升高则加重肾功能损害。
Nitrite indirect method was used to determine the changes of serum NO and NO in patients with chronic renal failure at different stages of disease and before dialysis, and compared with age-matched healthy people. The results showed that: ①No difference was found between serum NO and normal control group in patients with decompensated renal disease and azotemia, but not in uremic patients; ②The concentration of NO after hemodialysis was significantly lower than that before dialysis. Prompted the normal concentration of NO play a protective role on renal function, but the abnormal increase in NO concentration increased renal dysfunction.