论文部分内容阅读
目的:观察天麦消渴片干预治疗糖耐量异常患者的疗效。方法:120例糖耐量异常(IGT)患者,随机分为两组,每组60例。在饮食、运动控制基础上,治疗组给予天麦消渴片0.24 g/次,2次/d;对照组给予安慰剂。观察两组患者治疗2年后空腹血糖(FPG)、葡萄糖耐量试验(OGTT)后2 h血糖(2 hPG)、总胆固醇(TC)、甘油三脂(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、胰岛素抵抗指数(HOMA-IR)、胰岛素敏感指数(ISI)、空腹胰岛素(FINS)、OGTT后2 h胰岛素(PINS)、体重指数(BMI)、腰臀比(WHR)的变化。结果:治疗组FPG,2 hPG,TC,TG,LDL,HDL,HOMA-IR,FINS,PINS水平均明显下降,且疗效优于对照组(P<0.05);安慰剂组糖尿病的转归率为10%,天麦消渴片组糖尿病的转归率为5%,两组比较差异有统计学意义(P<0.05)。结论:天麦消渴片能够降低胰岛素抵抗,改善IGT,并且可以降低IGT患者糖尿病的发病率。
Objective: To observe the therapeutic effect of Tianma Xiaoke Tablet on patients with impaired glucose tolerance. Methods: One hundred and twenty patients with impaired glucose tolerance (IGT) were randomly divided into two groups (n = 60 in each group). On the basis of diet and exercise control, the treatment group was given Tianma Xiaoke piece 0.24 g / time, 2 times / d; the control group was given placebo. The levels of fasting blood glucose (FPG), 2h blood glucose (2hPG), total cholesterol (TC), triglyceride (TG), low density lipoprotein , HDL-C, HOMA-IR, ISI, FINS, PINS, BMI, Hip Ratio (WHR) changes. Results: The levels of FPG, 2 hPG, TC, TG, LDL, HDL, HOMA-IR, FINS and PINS in the treatment group were significantly lower than those in the control group (P <0.05) The prevalence of diabetes in Tianma Xiaoke Tablet group was 5%, with a significant difference between the two groups (P <0.05). Conclusion: Tianma Xiaoke Tablet can reduce insulin resistance, improve IGT, and can reduce the incidence of IGT patients with diabetes.