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[目的]探究我国汉族人群血管紧张素转换酶(ACE)基因插入/缺失(I/D)多态性与原发性高血压(EH)之间的关系。[方法]收集国内外2000年1月—2016年1月间发表的关于我国汉族人群ACE基因I/D多态性与EH关系的文献29篇,共计5 485例原发性高血压患者,4 878例健康对照。提取病例组与对照组基因型及等位基因的分布数据,应用Stata 12.0软件,利用随机效应或固定效应模型合并效应值,并对结果进行发表偏倚的检验。[结果]与II基因型相比,ID基因型患高血压OR=1.05(95%CI:0.92~1.19),DD基因型患高血压OR=1.66(95%CI:1.34~2.05)。与I等位基因相比,D等位基因患高血压合并OR=1.25(95%CI:1.12~1.40)。漏斗图、Egger法检验以及失安全系数等结果均表明此次Meta分析存在发表偏倚的可能性较小。[结论]我国汉族人群携带DD基因型及D等位基因者能增加EH发病风险。
[Objective] To explore the relationship between ACE gene insertion / deletion (I / D) polymorphism and essential hypertension (EH) in Chinese Han population. [Methods] A total of 29 literatures about ACE gene I / D polymorphism and EH in Chinese Han population were collected from January 2000 to January 2016 at home and abroad, totaling 5 485 cases of essential hypertension, 4 878 healthy controls. The data of genotype and allele distribution in case group and control group were extracted. Stata 12.0 software was used to combine the effect values with random effects or fixed effects model, and the results were tested for publication bias. [Results] Compared with genotype II, ID genotype had hypertension of 1.05 (95% CI: 0.92-1.19) and genotype DD of hypertension was 1.66 (95% CI: 1.34-2.05). Compared with the I allele, the D allele was associated with hypertension with OR = 1.25 (95% CI: 1.12-1.40). Funnel chart, Egger test, and loss of safety factors and other results indicate that the publication of the Meta analysis of publication bias is less likely. [Conclusion] The DD genotype and D allele in Chinese Han population can increase the risk of EH.