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目的 通过检测结直肠癌患者血清中sCD5 4、sCD4 4浓度的变化,了解其与肿瘤分期、预后以及肿瘤转移间的关系。方法 应用夹心ELISA和一步ELISA法对己确诊的32例结直肠癌患者血清中sCD5 4、sCD4 4的浓度进行测定,A期6例,B、C期18例,8例术后发现广泛转移,其余8例为D期。另设青年组和老年组作为对照,男女各半。结果 两者在男性和女性中水平是基本稳定的,性别不是分析血清中sCD5 4、sCD4 4水平的因素(均P >0 .0 5 ) ,16例广泛转移者和10例B、C期患者、6例A期患者以及对照组sCD5 4、sCD4 4的浓度相比差异均显著(P <0 .0 1) ,sCD5 4、sCD4 4间存在正相关关系,提示sCD5 4、sCD4 4水平与结直肠癌的转移密切相关。结论 结直肠癌转移的多个环节存在相关性,sCD5 4、sCD4 4可作为结直肠癌转移的标志,对预后预测有帮助,同时有助于术前手术范围的确定,为术后的综合治疗提供了理论依据
Objective To detect the changes of sCD5 4 and sCD4 4 levels in serum of patients with colorectal cancer, and to study their relationship with tumor stage, prognosis and tumor metastasis. Methods Serum levels of sCD5 4 and sCD4 4 in 32 patients with colorectal cancer confirmed by sandwich ELISA and one-step ELISA were determined. Six cases were in stage A, 18 cases were in stage B and C, 8 cases were found to have extensive metastasis, The remaining 8 cases for the D period. Another set of youth groups and elderly group as a control, men and women in half. Results The levels of sCD5 4 and sCD4 4 in serum were not significantly different between men and women (all P> 0.05), 16 patients with extensive metastasis and 10 patients with stage B and C , SCD5 4 and sCD4 4 in 6 cases of stage A patients and control group, there was a significant difference (P <0 01), there was a positive correlation between sCD5 4 and sCD4 4, suggesting that sCD5 4, sCD4 4 level and node Rectal cancer metastasis is closely related. Conclusions There is a correlation between multiple stages of colorectal cancer metastasis. SCD5 4 and sCD4 4 can be used as markers for the metastasis of colorectal cancer, which is helpful for the prediction of prognosis. At the same time, it is helpful to determine the scope of preoperative surgery and is a comprehensive postoperative treatment Provided a theoretical basis