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探讨cagⅡ在胃十二指肠疾病患者幽门螺杆菌（H．pylori）中的检出率及其与H．pylori相关性疾病的关系。方法：H．ylori菌株分离自107例胃十二指肠疾病患者，其中慢性胃炎67例，消化性溃疡34例，胃癌6例。采用聚合酶链反应（PCR）技术，对107株H.pylori菌株cagⅡ中的597bp片段进行扩增。结果：107株H．pylori菌株的cagⅡ阳性检出率为69．2％（74／107），慢性胃炎（64．2％）、消化性溃疡（79．4％）和胃癌（4／6）组的检出率无显著差异（P＞0．05）。结论：cagⅡ在不同胃十二指肠疾病患者感染的H.pylori中均有检出，其分布与不同H．pylori相关性疾病的关系并不十分密切，cagⅡ在H．pylori致病中的意义还有待进一步研究。
To investigate the detection rate of cag Ⅱ in H.pylori in patients with gastroduodenal disease and its correlation with H. pylori. pylori-related diseases. Method: H. Ylori strains isolated from 107 cases of gastroduodenal disease patients, including 67 cases of chronic gastritis, peptic ulcer in 34 cases, 6 cases of gastric cancer. A 597 bp fragment of 107 strains of H. pylori cag Ⅱ was amplified by polymerase chain reaction (PCR). Results: 107 strains H. The detection rate of cagⅡin the pylori strain was 69.2% (74/107), the detection rate of chronic gastritis (64.2%), peptic ulcer (79.4%) and gastric cancer (4/6) Significant difference (P> 0.05). Conclusion: cag Ⅱ is detected in H. pylori infected with different gastroduodenal diseases, its distribution is different from that of H. pylori. The relationship between pylori-related diseases is not very close, cag Ⅱ in H. The significance of pylori pathogenesis remains to be further studied.