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头孢吡肟为第四代半合成头孢菌素,其抗菌谱广、低毒高效,广泛用于临床。慢性肾功能衰竭患者药代动力学与正常人相比有显著变化,其主要影响在于降低药物清除排泄。在临床治疗过程中常有因忽视肾功能衰竭对药物代谢的影响而引起神经系统的异常〔1〕。我院血液净化中心于2008年4月
Cefepime is the fourth generation of semi-synthetic cephalosporins, its broad antibacterial spectrum, low toxicity and high efficiency, widely used in clinical. Pharmacokinetics in patients with chronic renal failure has a significant change compared with normal people, the main effect is to reduce drug clearance excretion. Often in the clinical treatment of renal failure due to neglect of the impact on drug metabolism caused by the nervous system abnormalities 〔1〕. Our hospital blood purification center in April 2008