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目的:探讨影响上皮性卵巢癌预后的因素。方法:对64例卵巢上皮性癌的病例资料进行回顾性分析, 26例早期(Ⅰ-Ⅱ)病人以全子宫切除加双附件切除为主,38例晚期(Ⅲ级及以上)以肿瘤减灭术为主,术后化疗以 CAP方案为主(环磷酰胺、阿霉素、顺氯氨铂)。结果:早期患者存活率明显高于晚期患者(P<0．01)。38例晚期患者中,理想的肿瘤减灭术(无残灶或残灶<2 cm)者存活率明显高于不理想的肿瘤减灭术(残灶≥2 cm)者(P <0．05)。术后化疗次数≥6次者与<6次者存活率差异有统计学意义(P<0．05)。分化程度对预后有明显影响 (P<0．05),但年龄及病理类型对预后影响差异无统计学意义(P>0．05)。肿瘤的临床分期、残灶大小及化疗次数对预后影响较大。结论:早期诊断、首次手术彻底以及化疗疗程≥6次是改善上皮性卵巢癌预后的关键。
Objective: To explore the factors affecting the prognosis of epithelial ovarian cancer. Methods: Retrospective analysis was performed on 64 cases of epithelial ovarian cancer. 26 cases of early (I-II) patients were treated with total hysterectomy and double adnexectomy, and 38 cases of advanced (grade III and above) tumors were eliminated. The main technique was postoperative chemotherapy with CAP regimen (cyclophosphamide, doxorubicin, and cisplatin). Results: The survival rate of early patients was significantly higher than that of late patients (P<0.01). In 38 patients with advanced disease, the survival rate of the ideal tumor reduction surgery (without residual or residual lesions <2 cm) was significantly higher than that of undesired tumor reduction surgery (residues≥2 cm) (P < 0.05). ). The survival rate of postoperative patients with ≥6 times of chemotherapy and <6 times had significant difference (P<0.05). The degree of differentiation had a significant influence on the prognosis (P<0.05), but the difference in age and pathological type had no statistical significance (P>0.05). The clinical stage, size of the remnants and the number of chemotherapy times have a significant impact on the prognosis. Conclusion: Early diagnosis, complete first surgery, and chemotherapy treatment ≥ 6 times are the key to improve the prognosis of epithelial ovarian cancer.