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目的探讨连续肾脏替代疗法(CRRT)在抢救重度有机磷农药中毒中的临床效果。方法选择2010年1月至2013年8月重度有机磷农药中毒患者60例,随机分为治疗组和对照组,每组30例,对照组予常规阿托品及解磷啶治疗,治疗组在常规治疗的基础上予CRRT,比较两组意识改善时间(昏迷至清醒时间)、机械通气时间、胆碱酯酶活力恢复正常所需时间和平均住院时间。结果与对照组相比,治疗组意识改善时间、机械通气时间、胆碱酯酶恢复时间和平均住院时间均明显缩短,差异有统计学意义(P<0.05)。结论连续肾脏替代疗法治疗重度有机磷中毒能有效改善临床症状,提高临床疗效。
Objective To investigate the clinical effect of continuous renal replacement therapy (CRRT) on salvage of severe organophosphorus pesticide poisoning. Methods Sixty patients with severe organophosphorus pesticide poisoning from January 2010 to August 2013 were randomly divided into treatment group (n = 30) and control group (n = 30). Patients in control group were treated with conventional atropine and dephosphorodine, On the basis of CRRT, the time of consciousness improvement (coma to awake time), the time of mechanical ventilation, the time required for cholinesterase to return to normal and the average hospital stay were compared. Results Compared with the control group, the time of improvement of consciousness, the time of mechanical ventilation, the recovery time of cholinesterase and the average length of stay in the treatment group were significantly shortened (P <0.05). Conclusion Continuous renal replacement therapy for severe organophosphate poisoning can effectively improve clinical symptoms and improve clinical efficacy.