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目的 :观察祛毒胶囊对LPS诱导的狼疮样模型小鼠几项免疫指标和病理改变的影响 ,探讨祛毒胶囊治疗SLE的可能机制。方法 :用ELISA试剂盒检测血清中的白细胞介素 - 6 (IL - 6 )、干扰素 -γ(IFN -γ)、和肿瘤坏死因子 -α(TNF -α)水平 ,对肝肾组织常规HE染色。结果 :(1)血清中IL - 6、IFN -γ及TNF -α水平各治疗组与模型组比较 ,差异有显著性 (p <0 .0 5 ) ;(2 )病理结果显示模型鼠肝肾炎性改变 ,治疗组炎性改变减轻。结论 :祛毒胶囊对狼疮样小鼠血清中IL - 6、IFN -γ及TNF -α的分泌有抑制作用 ,能明显改善其病理状态。
Objective: To observe the effect of Qi Du capsule on several immune indexes and pathological changes of lupus-like model mice induced by LPS, and to explore the possible mechanism of Qi Du capsule for treating SLE. METHODS: Serum levels of interleukin-6 (IL-6), interferon-γ (IFN-γ), and tumor necrosis factor-α (TNF-α) levels were measured using an ELISA kit. dyeing. Results: (1) The levels of serum IL-6, IFN-γ and TNF-α in the treatment groups were significantly different from those in the model group (p < 0.05). (2) Pathological results showed that the model rats had hepatonephritis With sexual changes, the inflammatory changes in the treatment group were lessened. Conclusion: Qi Du Capsule can inhibit the secretion of IL-6, IFN-γ and TNF-α in serum of lupus-like mice, and can obviously improve the pathological state.